Show Beneficial Results
Flavocin’s unique formula is
a therapeutic agent for the management of osteoarthritis
and the healing and protective effects of the ingredients
in Flavocin are well documented. More than two decades
of research studies, publications and abstracts have
reported on the health benefits of its key ingredient…
a naturally occurring plant compound extracted from the
seeds of the vitis vinifera.
Known by several trade names such as oligomeric
proanthocyanidin complexes (OPCs), or bioflavanol,
or flavan-3-ol, this active ingredient in Flavocin
has been awarded United States Patent 4,963,527.
Now available in the U.S., Flavocin contains
the ingredient tested and successfully used by Doctors
in Europe for decades and is now available without a
of Orthopaedic Surgeons gives
official "green light" to arthritis ingredient in
In a dietary supplement market that
is under constant government and media scrutiny, there
are certain things that you as a smart consumer should
watch out for.
For example, other ordinary joint formulas
may use a less pure form of glucosamine called glucosamine
sulfate. But Flavocin uses glucosamine HCl…which
is 99% pure. By comparison, the glucosamine sulfate
found in ordinary formulas is only 26% pure.
In fact, Flavocin Glucosamine HCl delivers
83.1% active glucosamine while the Glucosamine Sulfate
supplies a meager 47.8%.
That means that in order to get the equivalent
amount of glucosamine found in Flavocin… your
dog would need almost twice as much glucosamine sulfate!
And recently, the American Academy of
Orthopedic Surgeons2 gave the official “green
light” to this arthritis ingredient found in Flavocin,
saying it might actually be as beneficial as many widely
used non-steroidal anti-inflammatory drugs in the treatment
Clinical Studies Don't Lie
It is also important to know... that Flavocin packs
a whopping 500 mg of Glucosamine HCl in every chewable
tablet! That’s critical because recent research
shows that to effectively treat joint problems in dogs,
your dog needs 500 mg for every 30 pounds of body weight.
Most ordinary joint formulas for dogs only have 250
mg of glucosamine... or even less in their products!
I don’t know about you... but I don’t want
to have to give my dog six, seven or even eight pills
a day. What a hassle... and it can be a lot more expensive
Clinical tests show that the daily consumption of the
key ingredients in Flavocin not only can provide powerful
relief from the symptoms of arthritis in dogs… but
they also may help protect against disease and the effects
of aging. And that’s what makes Flavocin so different
from ordinary joint formulas, and so good for your dog.
By combining the patented OPCs in Flavocin
with two already proven nutrients—
Glucosamine HCl and Chondroitin Sulfate—plus Zinc,
Cysteine, Calcium, and Vitamin C
into an advanced joint and antioxidant formula, relief
for aging dogs could be close at hand. Here’s
Many scientists now believe that oxidative stress and
“free-radicals” may be the root cause of
more than 60 diseases including certain types of cancer,
cataracts, and arthritis… as well as the aging
As your dog grows older the production of free-radical
fighting enzymes decreases… creating even more
oxidative stress and further damage to your dog. As
this happens every part of your dog’s body gradually
Scientists also believe that the best way to fight these
free-radicals and oxidative-stress is with something
The powerful blend of micronutrients and antioxidants
like those found in Flavocin can help maintain optimum
health and provide nutritional support for healthy joints
and connective tissue.
With a unique flavoring technology that
makes the chewable tablets “taste just like a
treat”… the continued use of Flavocin may
help reactivate the natural healing process... keeping
your dog active, healthy, and happy throughout its life.
While the many health benefits of Flavocin
seem almost too good to be true… Flavocin’s
micronutrients have been tested in well-controlled clinical
In 1987, Dr. Shinji Uchida and his team
of researchers demonstrated that the antioxidant bioflavanols
found in Flavocin were up to 50 times more effective
than vitamin E as a free radical scavenger.
In the "Review of the Scientific
Research on Pycnogenols", June 1992 H
Liers reported, “The results show that the dimeric
proanthocyanidins are nearly 20 times more effective
than vitamin C at trapping oxygen radicals.”
In fact, to equal the antioxidant properties found in
just 3 Flavocin chewable tablets you would need to give
your dog… 25 six-ounce glasses of orange juice (vitamin
C) and 447 eight-ounce glasses of soy milk (vitamin E).
Research also suggests that the OPCs can increase the
total antioxidant capacity and stimulate defenses in blood.
But it gets even better.
It is believed that the most dangerous free-radical produced
by your dog’s body as it gets older is called the
hydroxyl radical. It is so damaging because it
directly attacks DNA—the building block of all cells.
Research demonstrates that OPCs can “search and
destroy” this dangerous hydroxyl free-radical. And
that’s not all.
Research also shows that the OPCs in Flavocin may be superior
to other antioxidants because its protective effects are
multiplied in the body, working with other antioxidants
by increasing their free-radical fighting effects. This
is due to its ability to “recycle” antioxidants
after they have quenched or destroyed free-radicals, thereby
extending the life of free-radical fighting antioxidants.
|85.7% of the
Dogs with Hip Dysplasia
The active ingredient
in Flavocin has been tested in dogs with arthritis secondary
to canine hip dysplasia. The study was a double-blind,
placebo controlled, 14-week clinical evaluation.
|The results indicated improvement
in those animals using the ingredient in Flavocin
as opposed to the placebo group: 85.7%
of the subjects in the group using the
active ingredient showed improvement
compared to the 9.1% showing improvement in
the placebo group.
Results of this study have been presented
at the 24th Annual Veterinary Orthopedic Society
Conference in Montana, The European College of
Veterinary Surgeons annual meeting in Versailles,
France and the Washington State Veterinary Medical
Association Meeting. The results have also been
presented at the Voorjaarsdagen Annual International
Veterinary Congress meeting in Amsterdam, Holland.
DESTROY Free-Radicals BEFORE
they Destroy Your DOG
Free radicals damage your dog’s healthy
cells and in turn impair the body's normal functions.
Free radicals are produced from:
||Normal respiration and
||Exposure to air pollutants
||Radiation from X-rays
How do free radicals affect
your dog’s body?
Free radicals are known today to be one of the most
destructive forces in the body of an aging animal.
This is especially true when talking about your dog's
joints and other tissues.
Free radicals cause a loss of cellular flexibility and
strength, and can cause joints and cartilage to become
stiff, cloud vision, cause arteries to lose their elasticity,
inflammation, and gastrointestinal and liver disorders.
Research has shown that free radicals are involved
in many age-related conditions such as:
||Kidney and liver disorders
||Weakened immune system
Healthy versus Arthritic Joint Components
All joints are filled with a lubricant called synovial
fluid. Normally, your dog’s natural antioxidant
enzymes clean free radicals from the synovial fluid, keeping
the joint properly lubricated for free movement. However,
poor nutrition, aging and stress can contribute to the
under production of the natural enzymes, resulting in
free radical damage to the cells in your dog’s joints
and joint problems in dogs. This cellular damage leads
to friction, decreasing the health of joints and impacting
their ability to function.
How do we combat free radicals?
Supplementation with antioxidants has
been shown to help reduce the effects of free radicals
on the aging body. Antioxidants diminish the damage
caused by free radicals to cells by neutralizing the
unstable structure and converting it to a harmless compound
that may be safely removed from the body.
Antioxidants are likely to be most beneficial for
older animals, animals that are very active or undergoing
strenuous training, and animals under stress.
Antioxidants will help maintain optimum
health in your dog’s gastrointestinal and cardiovascular
systems, liver, kidneys, eyes and immune systems. They
help protect cartilage and collagen in the joints
from free radical damage, and allow nutrients to
be effectively used for new cell growth and cell repair.
As pets become older, antioxidants become even more
important in the fight against free radicals and their
associated damage to cells in joints and other tissues.
All animals are at risk for joint disease. Most animals
have sustained damage to cartilage in joints by middle
age… and for most dogs that’s about
5 years of age!
Many factors can affect joint health and
the integrity of cartilage. Among them are diet, genetic
make-up and activity levels. Each animal's genetic code,
for example, can influence the thickness and durability
of its cartilage and the predisposition to arthritis.
Regardless of the cause for joint problems,
nutrition, especially antioxidant supplementation, is
particularly important in maintaining healthy joints.
And that’s where Flavocin can help.
Flavocin contains a scientific blend
of four potent antioxidants: Vitamin C, Zinc, Cysteine
and Bioflavanol (flavan-3-ol)… the most powerful
antioxidant ever discovered. In fact, studies show it
to be 20 times stronger than vitamin C and 50 times
more powerful than vitamin E in fighting free radicals.
REDUCING joint pain and inflammation
for Dogs with Arthritis
If your dog is suffering from dog joint problems…
one of the most common symptoms is pain and inflammation.
Research shows that OPCs like those found
in Flavocin can selectively bind to connective tissue
of joints, preventing inflammation and lessening of
pain. It does this by preventing the release of histamine—a
key factor in swelling and inflammation. In fact, studies
dating back to as early as 1947 showed this to be one
of the very first benefits of the OPCs.
Because it has the ability to strengthen
vascular walls, Flavocin’s active ingredient may
help your dog to repair injuries faster. An Australian
study showed that participants who took the active compound
for 10 days after their injuries had less swelling than
those that didn’t take it.
Scientists from the University of Florence
in Italy studied the effects of the Flavocin active
compound on patients with swelling in the legs. After
60 days, the pain was totally reduced in 67% of those
participating and swelling disappeared in a whopping
63%. Plus, double-blind studies from France showed the
OPCs can reduce inflammation after surgery.
Other studies indicate that OPCs
may be an effective alternative to aspirin. These OPCs
have shown a better risk-ratio compared to aspirin,
meaning it has many of the same benefits of aspirin—with
a lot less side effects.
PROTECTING cartilage from further damage
with Joint Problems
Certain types of arthritis
in dogs can be traced to metabolic changes taking place
in cartilage. Dogs with arthritis have cells in the
cartilage that go crazy and start producing a destructive
enzyme that wipes out cartilage faster than it can be
produced. The active ingredient in Flavocin has been
shown to stop further damage to cartilage by blocking
the enzyme that destroys cartilage… helping to
improve flexibility and mobility as your pet ages.
If you really want to know the science
behind it… Gosh and Smith*, two leading researchers
coined the term “chondroprotective” to illustrate
this type of protection found in Flavocin. They define
chondroprotective agents as those substances with the
- Inhibit degradative enzymes (e.g.,
collageneses, cathepsins, hyaluronidase, chondroitinases)
or inflammatory mediators (e.g., interleukin-1, tumor
necrosis factor, PGE2)
- Remove or prevent formation of fibrin,
thrombi, plaque in synovium and/or subchondral blood
REPAIRING and RESTORING damaged cartilage
and joint tissue in Dogs with Arthritis
Cartilage is a body tissue that lacks
its own blood supply. Because of that, dogs rely on
fluids to penetrate and feed their joints with nutrients.
The problem is… dogs with joint problems often
have an inadequate supply of nutrients “feeding”
their joint tissue. This limited supply actually creates
more damage and what’s worse is… it reduces
your dog’s ability to heal itself and generate
new tissue. The good news is… Flavocin supplies
the raw materials that have been shown to help repair
and restore damaged joints. In fact there are five decades
of medical research from around the world supporting
the key ingredients in Flavocin.
By giving your dog Flavocin daily, you
can increase the flow of nourishment, by providing nutritional
support important for healthy joints. Plus, because
these key ingredients have shown the ability to re-infuse
joints with greater levels of nutrient-rich water this
also “plumps-up” the spongy cartilage providing
more shock absorbing comfort. And that’s important
because water is the main ingredient in healthy cartilage—in
fact, as much as 65 to 80 percent of cartilage is water.
STIMULATING the growth
of NEW cartilage in Dogs with Arthritis
Healthy cartilage is made up of four parts:
- Cells (called chondrocytes)
Chondrocytes are cells in joints that
are responsible for stimulating the growth of new cartilage.
Your dog’s body has a natural healing process
that uses these chondrocytes to remove unhealthy and
damaged cartilage and replace it with newer healthier
cartilage. It is a wonderful process… as long
as it’s working properly.
The problem is… dogs with joint
problems can’t stimulate enough new cartilage
to keep up with the cartilage that’s being destroyed.
The reason? They lack the proper nutritional building
blocks required to stimulate enough new growth. Flavocin
provides the key micronutrients shown to stimulate the
production of chondrocytes according to published research.
This in turn produces more collagen (collagen
gives cartilage its elasticy and shock absorbing qualities)
and proteoglycans (proteoglycans attract water and keep
the cartilage sponge-like and lubricated for maximum
shock-absorption). This results in a much healthier
environment for the creation of new cartilage.
1,2 Statements herein are based
on published public information and do not apply affiliation,
sponsorship or endorsement of Flavocin by the American
Academy of Orthopaedic Surgeons or Johns Hopkins University
or any of its doctors or employees.